Pathology EMQ template.

Name: Sayjel Patel

Candidate number: 00427630

Theme: Paediatric Haemotology

OPTION LIST

A	Acute lymphoblastic leukaemia	I	Haemolytic uraemic syndrome
B	Acute myeloid leukaemia	J	Sickle cell disease
C	Alloimmune haemolytic anaemia	K	Sickle cell trait
D	Alloimmune thrombocytopenia purpura	L
E	Autoimmune thrombocytopenic purpura	M
F	Beta thalassaemia intermediate	N
G	Beta thalassaemia major	O
H	Glucose-6-phosphate dehydrogenase (G6PD) deficiency	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. This condition often presents in the first 6 months of life with ‘hand-foot’ syndrome, splenic sequestration, a decrease in haemoglobin F synthesis and an increase in haemoglobin S synthesis.

2. Treatment for this condition: lifelong blood transfusions, and Fe chelation in older children. It is the most severe form of this condition.

3. This condition should be considered when a child develops pallor and jaundice. The blood count and film shows anaemia and irregularly contracted cells.

4. This condition is characterised by the triad of microangiopathic haemolytic anaemia, thrombocytopenia and acute renal failure. It is usually the result of an infection by Escherichia coli, which secretes verocytotoxin. This toxin damages endothelial cells.

5. Presents in infants and children with bruising, petechiae and blood blisters in the mouth. No blasts are seen on the blood film. Hb and WCC are normal. It is an acute, self-limiting condition.

ANSWERS

1. J

2. G

3. H

4. I

5. D